Biological prophylaxis as a system of measures aimed at enhancing children s resistancetotoxic exposures

It is demonstrated that some diseases and sub-clinical conditions could be conclusively associated with environmental exposures to toxic metals and some organic chemicals emitted by industries characteristic of this region.We developed a concept of the biological prophylaxis (BP) meaning a complex of methods aimed at the increase in the effectiveness of general and specific host s biological protective mechanisms. Based on theoretical premises, we propose a complex of notoriously innocuous bio-protectors with expected beneficial influence on toxicokinetics and toxicodynamics of chemicals in combinations characteristic of a particular urban area. Then we test this complex on an animal experimental model of the combined toxicity of those chemicals. The BP complexes (BPC) proved effective in the animal experiments are subject to controlled field trials on restricted groups of children aged 4-7 under medical and laboratory supervision.