The significance of genes’ polymorphism of hemocoagulation disease and folic acid cycle in infants with periventricular ischemia

Results of gene polymorphisms investigation in 30 children with severe periventricular ischemia are presented. 80% of them had relatives with variety thrombosis under the age of 50 and all of them had 3-8 SNP-mutations. The most dramatic allele F5: G1691A was not registrated. More than 30% of newborns had two polymorphic genes of folic acid and 16,7% showed combination of folic acid with thrombophilia polymorphisms including MTHFR: C677T. We propose the prescribing of thrombophilic and folic acid SNP-mutations investigations for infants in perinatal period with severe and critical neurological brain damages.

Subject article:

Number of pages in the journal:

39 pages