During our study of clinical and immunological features of severe varicella with central nervous system damage, we have surveyed 11 children aged 4 to 13 years old. The clinical picture of vari-cella in this group of children is characterized by a high intensity of exanthema and febrile fever during the period of rash in most patients. Neurological disorders occurred on the 3-7 day since the appearance of skin rash and had a favorable outcome. The immune status of these children is char-acterized by decrease of immunoregulatory cytokine-producing T-lymphocytes (CD3 + / IFNγ +, CD3 + / TNFα +, CD3 + / IL4 +, CD3 + / IL2 +), which can provoke inadequate immune responses and develop generalized forms of the disease.