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Various studies indicate the presence of psychological factors, including, personality traits that affect the occurrence, course and prognosis of cardiovascular diseases. Purpose: to identify the individual typological characteristics of patients with primary myocardial infarction, depending on the type of response to the disease. Sixty patients with primary myocardial infarction were examined. After the analysis of the revealed types of response to the disease (TRD), 3 groups of patients were identified: 1) with ergopathic, anosognotic and mixed TRD, including ergopathic and anosognosic, ergopathic and sensitive TRD; 2) with an alarming and diffuse (consisting of 4 or more types) TRD; 3) with a “clean” harmonious TRD. Individual-typological features inherent in each of the groups under study and correlation links between them are revealed. For successful rehabilitation after a previous illness and reducing the risk of repeated episodes of the disease, patients from the first two groups need a correction of the behavior strategy and additional psychological support.