The article presents the results of an empirical study of life meaning orientations in female students of the 1st-6th courses of the Ural State Medical University. The authors of the article identify the theoretical aspects of the development of life orientations during the period of study at the university, reveal the features of the value-motivational sphere in girls aged 18 to 25 years. The study was conducted using the test of life orientations test (test of life orientations) developed by D.A. Leontiev. According to the results of the study, it was revealed that young girls are characterized by a high degree of responsibility for their actions and orientation towards the realization of life tasks aimed at education and professional activity. However, the students also showed an uncertain attitude towards their future, the presence of fear and anxiety about their lives and achievements.