The basis for the prevention of hospital infection is a set of measures aimed at preventing endogenous and exogenous infection. To improve the quality of disinfection measures in medical institutions of various profiles, it is necessary to analyze the funds used, estimated need/ expended and safety. Objective: to analyze the modern disinfectants and antiseptics used, the estimated need and expenditure in the oncological medical organization. Methods: quarterly plans and logs for the use of antiseptic and disinfectants in the State Autonomous Healthcare Institution of the Sverdlovsk Region “Sverdlovsk Regional Oncological Dispensary”. Results: The following antiseptic and disinfectants are used in the State Medical University: BiaKlin (napkins), Extra-septic tank (napkins), Averon, Omnik washing, Tamitsid RTU, Isoseptin, Bio-Soft (soap). Almost all products include several active ingredients of different groups at once, that is, they are combined. The active substances are selected so that they potentiate the action, but offset or compensate for each other’s shortcomings, have a broad effect and are low-toxic. Analysis of the estimated need and use of disinfectants in various departments of the cancer dispensary revealed the correspondence of these parameters for the reporting period. Conclusions: Modern combined disinfectants and antiseptics with a wide range of antimicrobial effects and low toxicity are used in the oncological medical facility. The most common median units were Averone, Omnicellular, and Isoseptin. The correspondence of the estimated need and consumption of disinfectants for the reporting period was revealed, which indicates a high level of organization and planning of disinfection measures in the represented medical institution. The products with the highest specific gravity in the analysis of estimated needs and acquired needs belong to the group of disinfectants for disinfection, pre-sterilization cleaning, and sterilization of medical devices.